Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity

TE Van Rheenen; E Ringin; D Meyer; K Allott; J Wenzel; R Upthegrove; A Stainton; RKR Salokangas; S Ruhrmann; M Rosen; E Meisenzahl; E Maggioni; T Lichtenstein; R Lencer; J Kambeitz; U Dannlowski; DB Dwyer; K Chisholm; S Borgwardt; C Bonivento; A Bertolino; L Antonucci; N Koutsouleris; P Brambilla; C Pantelis; L Kambeitz-Ilankovic; SJ Wood

Journal article

Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity

TE Van Rheenen, E Ringin, D Meyer, K Allott, J Wenzel, R Upthegrove, A Stainton, RKR Salokangas, S Ruhrmann, M Rosen, E Meisenzahl, E Maggioni, T Lichtenstein, R Lencer, J Kambeitz, U Dannlowski, DB Dwyer, K Chisholm, S Borgwardt, C Bonivento Show all

European Neuropsychopharmacology | Elsevier BV | Published : 2026

DOI: 10.1016/j.euroneuro.2026.112800

Abstract

The latent structure and longitudinal stability of cognitive heterogeneity during the early course of mood and psychosis spectrum illness has not been well-studied. We determined the presence, stability and characteristics of latent cognitive profiles underlying a transdiagnostic sample of individuals at high risk for psychosis (CHR) or with a recent onset of psychosis (ROP) or depression (ROD). The sample comprised 666 CHR, ROP or ROD individuals. Latent Profile Analysis identified transdiagnostic cognitive profiles in baseline and 11-month follow up data. Latent Transition Analysis established the stability of these profiles and their transition probabilities. Profiles were characterised a..

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